p-Toluenesulfonic acid → 3-hydroxy-N'-(1-methylethylidene)-2-naphthohydrazide

HRID 844394ノート

反応式

HRID 844394 の反応式
[OH:1][C:2]1[C:3]([C:12]([NH:14][NH2:15])=[O:13])=[CH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[C:16]1(C)[CH:21]=CC(S(O)(=O)=O)=C[CH:17]=1>CC(C)=O>[OH:1][C:2]1[C:3]([C:12]([NH:14][N:15]=[C:16]([CH3:21])[CH3:17])=[O:13])=[CH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2

参加物

4

反応物 2

HCID 6101p-Toluenesulfonic acidHCID 726993-Hydroxy-2-naphthoic acid hydrazide

生成物 1

HCID 45219753-hydroxy-N'-(1-methylethylidene)-2-naphthohydrazide

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
20 °C

実験手順

A four neck flask (3 liters) equipped with a thermometer, a reflux condenser and a stirrer was charged with 121.2 g (0.6 mol) of 3-hydroxy-2-naphthohydrazide, 1.14 g (0.006 mol) of p-toluenesulfonic acid and 2 liters of acetone and then heated under reflux for 5 hours. The reaction liquid was cooled down to 20° C. or lower, and then crystal was filtered off and dried under reduced pressure, whereby the intended compound (slightly yellow crystal) was obtained.

後処理

  1. customA four neck flask (3 liters) equipped with a thermometer, a reflux condenser and a stirrer
  2. temperatureheated
  3. temperatureunder reflux for 5 hours
  4. customThe reaction liquid
  5. filtrationlower, and then crystal was filtered off
  6. customdried under reduced pressure, whereby the intended compound (slightly yellow crystal)
  7. customwas obtained

出典と根拠

ORDレコード
ord-5d6f44b48cc54f7980cfe0dbf05aba55
出典データセット
uspto-grants-2002_04
特許番号
US06380288B1

反応ノート

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