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2-Bromo-6-methylbenzoic acid → N-[(2-bromo-6-methylphenyl)carbonyl]-4-(1,3,6-trimethyl-2,4-dioxo-5-pyrimidinyl)-L-phenylalanine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Bromo-6-methylbenzoic acid | HCID 2735589 | — |
| 反応物 | 4-(1,3,6-trimethyl-2,4-dioxo-5-pyrimidinyl)-L-phenylalanine methyl ester | HCID 69336975 | — |
| 生成物 | N-[(2-bromo-6-methylphenyl)carbonyl]-4-(1,3,6-trimethyl-2,4-dioxo-5-pyrimidinyl)-L-phenylalanine | HCID 69335840 | — |
反応手順
N-[(2-bromo-6-methylphenyl)carbonyl]-4-(1,3,6-trimethyl-2,4-dioxo-5-pyrimidinyl)-L-phenylalanine was prepared from 4-(1,3,6-trimethyl-2,4-dioxo-5-pyrimidinyl)-L-phenylalanine methyl ester and 2-bromo-6-methylbenzoic acid using the general procedures described in example 7 and was obtained as a white solid: mp 240-242° C. FAB-HRMS m/e calcd for C24H24BrN3O5 (M+H) 514.0978, found 514.0965.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06380387B1 |
| 出典データセット | uspto-grants-2002_04 |
| ORD ID | ord-905cf08e4be54333872800debcccb844 |
| 出典メモ | uspto-grants-2002_04 |