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HRID 844855作成日：2026年10月27日

2-Fluoro-6-(trifluoromethyl)benzoic acid → N-[(2-fluoro-6-(trifluoromethyl)phenyl)carbonyl]-4-(1,3,6-trimethyl-2,4-dioxo-5-pyrimidinyl)-L-phenylalanine

https://huagongshe.com/reaction/844855

反応式

関与物質

役割名称HCID仕込み量
反応物2-Fluoro-6-(trifluoromethyl)benzoic acidHCID 688123—
反応物4-(1,3,6-trimethyl-2,4-dioxo-5-pyrimidinyl)-L-phenylalanine methyl esterHCID 69336975—
生成物N-[(2-fluoro-6-(trifluoromethyl)phenyl)carbonyl]-4-(1,3,6-trimethyl-2,4-dioxo-5-pyrimidinyl)-L-phenylalanineHCID 69336694—

反応手順

N-[(2-fluoro-6-(trifluoromethyl)phenyl)carbonyl]-4-(1,3,6-trimethyl-2,4-dioxo-5-pyrimidinyl)-L-phenylalanine was prepared from 4-(1,3,6-trimethyl-2,4-dioxo-5-pyrimidinyl)-L-phenylalanine methyl ester and 2-fluoro-6-(trifluoromethyl)benzoic acid using the general procedures described in example 7 and was obtained as a white solid: mp 218-220° C. ES-HRMS m/e calcd for C25H23F4N3O5 (M+Na) 530.1310, found 530.1317.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06380387B1
出典データセットuspto-grants-2002_04
ORD IDord-58dc209ead854fde94a201c82aecb56b
出典メモuspto-grants-2002_04