2,6-Lutidine → HCID 19881564、化合物

HRID 845107ノート

反応式

HRID 845107 の反応式
Br[CH:2]1[CH:8](Br)[CH2:7][CH2:6][N:5]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[C:4](=[O:22])[CH2:3]1.N1C(C)=CC=CC=1C>C1(C)C=CC=CC=1>[CH2:10]([N:5]1[CH2:6][CH:7]=[CH:8][CH:2]=[CH:3][C:4]1=[O:22])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]

参加物

4

反応物 2

HCID 79372,6-LutidineHCID 20133570HCID 20133570、化合物

生成物 1

HCID 19881564HCID 19881564、化合物収率 177.4%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A solution of 3.4 g (7.72 mmol) of 4,5-dibromo-1-dodecylazacycloheptan-2-one in 5.79 g (0.054 mol) of 2,6-lutidine was refluxed for 3 hours. After standing at room temperature for 20 hours, toluene was added, and the solution was filtered. The filtrate was concentrated in vacuo and distilled to give 3.8 g of a crude oil which was subjected to flash chromatography (silica gel; 3:1 petroleum ether/ether V/V) to yield pure product.

後処理

  1. filtrationthe solution was filtered
  2. concentrationThe filtrate was concentrated in vacuo
  3. distillationdistilled

出典と根拠

ORDレコード
ord-f07743fdfb204672823ba5ee3af3c388
出典データセット
uspto-grants-1988_07
特許番号
US04755535

反応ノート

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