Hydrochloric Acid → 4-Acetoxymethylindole

HRID 845230

反応式

HRID 845230 の反応式
[OH:1][CH2:2][C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[CH:5]=[CH:6][NH:7]2.[C:12](OC(=O)C)(=[O:14])[CH3:13].Cl.C(=O)(O)[O-].[Na+]>N1C=CC=CC=1.O.CCOCC>[C:12]([O:1][CH2:2][C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[CH:5]=[CH:6][NH:7]2)(=[O:14])[CH3:13]

参加物

8

反応物 4

HCID 313Hydrochloric AcidHCID 7918Acetic AnhydrideHCID 516892Sodium BicarbonateHCID 27734571H-indol-4-ylmethanol

生成物 1

HCID 201323834-Acetoxymethylindole

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 1049Pyridine溶媒HCID 3283Diethyl Ether溶媒

実験手順

4-Hydroxymethylindole (17 g) is heated in pyridine (12 ml) with acetic anhydride (11.9 ml) for three hours on the steam bath. After dilution with ether, the reaction mixture is first shaken out with 1N hydrochloric acid, then with saturated sodium bicarbonate solution and finally with water. The ether solution is evaporated. 20 g of 4-acetoxymethylindole remains.

後処理

  1. customThe ether solution is evaporated

出典と根拠

ORDレコード
ord-83b329542d554a09a2c16b88a5e07644
出典データセット
uspto-grants-1988_07
特許番号
US04757070

関連ノート

読み込み中…