Hydrazine hydrate (1:1) → 1,4-Dihydro-2,6-dimethyl-3-methoxycarbonyl-4-(2,3-dichlorophenyl)-5-(2-aminoethoxy)carbonyl-pyridine

HRID 845265ノート

反応式

HRID 845265 の反応式
[CH3:1][C:2]1[NH:3][C:4]([CH3:36])=[C:5]([C:20]([O:22][CH2:23][CH2:24][N:25]2C(=O)C3=CC=CC=C3C2=O)=[O:21])[CH:6]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[C:13]=2[Cl:19])[C:7]=1[C:8]([O:10][CH3:11])=[O:9].O.NN>C(OC)(C)(C)C>[CH3:1][C:2]1[NH:3][C:4]([CH3:36])=[C:5]([C:20]([O:22][CH2:23][CH2:24][NH2:25])=[O:21])[CH:6]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[C:13]=2[Cl:19])[C:7]=1[C:8]([O:10][CH3:11])=[O:9]

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 140116751,4-Dihydro-2,6-dimethyl-3-methoxycarbonyl-4-(2,3-dichlorophenyl)-5-(2-phthalimidoethoxy)carbonyl-pyridine

生成物 1

HCID 140116791,4-Dihydro-2,6-dimethyl-3-methoxycarbonyl-4-(2,3-dichlorophenyl)-5-(2-aminoethoxy)carbonyl-pyridine収率 51%

試薬・触媒・溶媒 1

HCID 15413tert-Butyl methyl ether溶媒

実験手順

Prepared by a method analogous to that of Example 1(b) from 10.0 g (19 mmol) of 1,4-dihydro-2,6-dimethyl-3-methoxycarbonyl-4-(2,3-dichlorophenyl)-5-(2-phthalimidoethoxy)carbonyl-pyridine and 2.84 ml (57 mmol) of hydrazine hydrate. 3.85 g (51%) of pale yellow crystals melting at 166°-167° C. obtained from tert.-butylmethyl ether.

出典と根拠

ORDレコード
ord-43ac57270ae34c909a973a788eda284c
出典データセット
uspto-grants-1988_07
特許番号
US04757080

反応ノート

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