2-Chloro-1,4-naphthoquinone → 2-Methoxy-1,4-Naphthoquinone

HRID 845543

反応式

HRID 845543 の反応式
Cl[C:2]1[C:3](=[O:13])[C:4]2[C:9]([C:10](=[O:12])[CH:11]=1)=[CH:8][CH:7]=[CH:6][CH:5]=2.[CH3:14][O-:15].[Na+]>O1CCCC1>[CH3:14][O:15][C:2]1[C:3](=[O:13])[C:4]2[C:9]([C:10](=[O:12])[CH:11]=1)=[CH:8][CH:7]=[CH:6][CH:5]=2

参加物

4

反応物 2

HCID 138912-Chloro-1,4-naphthoquinoneHCID 10942334Sodium Methoxide

生成物 1

HCID 168712-Methoxy-1,4-Naphthoquinone

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

A solution of 2-chloro-1,4-naphthoquinone (10.3 g) in tetrahydrofuran (100 mL) was treated with a suspension of sodium methoxide (3.20 g) in tetrahydrofuran (25 mL) at room temperature. After stirring overnight, the mixture was evaporated, and the residue was taken up in ether. The organic layer was washed with brine, dried, filtered and evaporated. Chromatography over silica gel gave 2-methoxy-1,4-naphthoquinone, m.p. 182°-183° C.

後処理

  1. customthe mixture was evaporated
  2. washThe organic layer was washed with brine
  3. customdried
  4. filtrationfiltered
  5. customevaporated

出典と根拠

ORDレコード
ord-111067d78c4e48748110f7d3c7226caa
出典データセット
uspto-grants-1988_07
特許番号
US04758587

関連ノート

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