反応式
O1C2C(=CC=CC=2)C(=O)C=C1C1C=CC=CC=1.O1CC1C[O:21][C:22]1[CH:31]=[C:30]2[C:25]([C:26](=[O:38])[CH:27]=[C:28]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[O:29]2)=[CH:24][CH:23]=1>>[OH:21][C:22]1[CH:31]=[C:30]2[C:25]([C:26](=[O:38])[CH:27]=[C:28]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[O:29]2)=[CH:24][CH:23]=1参加物
3
実験手順
7-2,3-Epoxypropoxy)flavone is useful as an intermediate for the preparation of 7-[3-(alkylamino)-2-hydroxypropoxy]flavones, which aminated flavones are disclosed in U.S. Pat. No. 4,495,198 to be particularly useful as antihypertensives. This patent shows the preparation of 7-(2,3-epoxypropoxy)flavone in low yields by reaction of 7-hydroxyflavone and an epihalohydrin in the presence of either sodium hydroxide and ethanol (59% yield) or potassium carbonate and acetone (68% yield after refluxing for 2 days).
出典と根拠
- ORDレコード
- ord-a63b6697ff4d4a61a2ffe0a4d59b2bac
- 出典データセット
- uspto-grants-1988_07
- 特許番号
- US04758678
関連ノート
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