Sodium Carbonate → Phthalimide

反応式

FC(F)(F)C1N=C(N2CCNCC2)C=CC=1.BrCC[N:20]1[C:24](=[O:25])[C:23]2=[CH:26][CH:27]=[CH:28][CH:29]=[C:22]2[C:21]1=[O:30].C(=O)([O-])[O-].[Na+].[Na+]>>[C:21]1(=[O:30])[C:22]2[C:23](=[CH:26][CH:27]=[CH:28][CH:29]=2)[C:24](=[O:25])[NH:20]1

参加物

反応物 3

HCID 10340Sodium Carbonate

HCID 113251H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)-

HCID 114247401-[6-(Trifluoromethyl)pyridin-2-yl]piperazine

生成物 1

HCID 6809Phthalimide収率 33%

実験手順

A mixture of 69.3 g of 1-[6-(trifluoromethyl) -2-pyridinyl]piperazine, and 129.6 g of N-(2-bromo-ethyl)phthalimide and 57.2 g of sodium carbonate is heated at reflux for 23 hours. The resulting precipitate is filtered off and the ethanol evaporated. The concentrate is dissolved in dichloromethane, washed with water, dried over magnesium sulfate, and evaporated. The resulting precipitate is recrystallized from isopropanol to give 39.5 g of 2-μ-[4-[6-(trifluoromethyl)-2-pyridinyl]-1-piperazinyl]ethyl]-1H-isoindole-1,3-dione (yield 33%).