Bis(1,3-dichloroisopropyl ether) → 5(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propylsulfonyl)phenyl)-2(3H)-furanone

HRID 846231

反応式

HRID 846231 の反応式
[C:1]([C:4]1[CH:29]=[CH:28][C:7]([O:8][CH2:9][CH2:10][CH2:11][S:12]([C:15]2[CH:20]=[CH:19][C:18]([C:21](=O)[CH2:22][CH2:23][C:24]([OH:26])=[O:25])=[CH:17][CH:16]=2)(=[O:14])=[O:13])=[C:6]([CH2:30][CH2:31][CH3:32])[C:5]=1[OH:33])(=[O:3])[CH3:2].ClCC(OC(CCl)CCl)CCl>C(Cl)(Cl)Cl>[C:1]([C:4]1[CH:29]=[CH:28][C:7]([O:8][CH2:9][CH2:10][CH2:11][S:12]([C:15]2[CH:20]=[CH:19][C:18]([C:21]3[O:25][C:24](=[O:26])[CH2:23][CH:22]=3)=[CH:17][CH:16]=2)(=[O:14])=[O:13])=[C:6]([CH2:30][CH2:31][CH3:32])[C:5]=1[OH:33])(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 93323Bis(1,3-dichloroisopropyl ether)HCID 122010L 648051

生成物 1

HCID 540070835(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propylsulfonyl)phenyl)-2(3H)-furanone

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

The compound of Example 29, (2.0 g, 4.197 mmoles) was suspended in chloroform (120 mls) to which was added 1,1-dichloromethylmethyl ether (10 ml). The reaction mixture was heated at 40° for 48 hours, and concentrated in vacuo. The residue was recrystallized to afford the title compound, m.p. 135°-136°.

後処理

  1. temperatureThe reaction mixture was heated at 40° for 48 hours
  2. concentrationconcentrated in vacuo
  3. customThe residue was recrystallized

出典と根拠

ORDレコード
ord-fc294c4efcd94dc0991c6afc5cb3ddbc
出典データセット
uspto-grants-1992_08
特許番号
US05135940

関連ノート

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