2,3-Difluoro-6-nitro-(2-p-toluenesulfonyloxypropyl)oxybenzene → 2,3-Difluoro-6-amino-[(2-p-toluenesulfonyloxypropyl)oxy]benzene

HRID 846336ノート

反応式

HRID 846336 の反応式
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([N+:9]([O-])=O)[C:3]=1[O:12][CH2:13][CH:14]([O:16][S:17]([C:20]1[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][CH:21]=1)(=[O:19])=[O:18])[CH3:15]>C(O)C.[Pd]>[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([NH2:9])[C:3]=1[O:12][CH2:13][CH:14]([O:16][S:17]([C:20]1[CH:21]=[CH:22][C:23]([CH3:26])=[CH:24][CH:25]=1)(=[O:19])=[O:18])[CH3:15]

参加物

4

反応物 1

HCID 146971942,3-Difluoro-6-nitro-(2-p-toluenesulfonyloxypropyl)oxybenzene

生成物 1

HCID 146971972,3-Difluoro-6-amino-[(2-p-toluenesulfonyloxypropyl)oxy]benzene

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a solution of 2.32 g of the compound obtained in Example 8 in 50 ml of ethanol was added 1 g of 5% palladium on charcoal, and the catalytic reduction was carried out under atmospheric pressure at room temperature for about 1 hour. The catalyst was removed by filtration, and the solvent was removed under reduced pressure to yield the titled compound. This product was used in the following reaction without purification.

後処理

  1. customThe catalyst was removed by filtration
  2. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-2dc506dc92d441378a47592ee4bf8a1c
出典データセット
uspto-grants-1992_08
特許番号
US05136059

反応ノート

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