Methyl iodide → N-(2,4-Dichloro-5-methoxyphenyl)acetamide

HRID 846501ノート

反応式

HRID 846501 の反応式
[CH3:1][C:2]([NH:4][C:5]1[C:10]([Cl:11])=[CH:9][C:8]([Cl:12])=[C:7]([OH:13])[CH:6]=1)=[O:3].[C:14](=O)([O-])[O-].[K+].[K+].CI>CC(C)=O>[CH3:1][C:2]([NH:4][C:5]1[C:10]([Cl:11])=[CH:9][C:8]([Cl:12])=[C:7]([O:13][CH3:14])[CH:6]=1)=[O:3]

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 27359882,4-Dichloro-5-hydroxyacetanilide

生成物 1

HCID 14593783N-(2,4-Dichloro-5-methoxyphenyl)acetamide収率 99.9%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A stirred mixture of 35.0 g (0.16 mole) of 2,4-dichloro-5-hydroxyacetanilide, 33.1 g (0.24 mole) of potassium carbonate, and 34.1 g (0.24 mole) of methyl iodide in 300 mL of acetone was heated at reflux for approximately 18 hours. The mixture was cooled and filtered. The filtrate was evaporated under reduced pressure to leave 37.4 g of 2,4-dichloro-5-methoxyacetanilide as a solid.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for approximately 18 hours
  3. temperatureThe mixture was cooled
  4. filtrationfiltered
  5. customThe filtrate was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-f2c8ea1609384ea7857ec011af102844
出典データセット
uspto-grants-1992_08
特許番号
US05136868

反応ノート

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