Piperazine → 2-Methyl-4-(piperazin-1-yl)pyrimidine

HRID 846844ノート

反応式

HRID 846844 の反応式
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH3:8])[N:3]=1.[NH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1>O1CCCC1>[CH3:8][C:4]1[N:3]=[C:2]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:7]=[CH:6][N:5]=1

参加物

4

反応物 2

HCID 4837PiperazineHCID 4244474-Chloro-2-methylpyrimidine

生成物 1

HCID 148385552-Methyl-4-(piperazin-1-yl)pyrimidine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

13 g of 4-chloro-2-methyl-pyrimidine were dissolved in 200 ml of tetrahydrofuran, and 17.5 g of piperazine were added. The reaction mixture was refluxed for 24 h. The precipitated piperazine hydrochloride was filtered off with suction and washed with tetrahydrofuran. Concentration of the solution in vacuo resulted in 19 g of 2-methyl-4-piperazino-pyrimidine, which was reacted without further purification.

後処理

  1. temperatureThe reaction mixture was refluxed for 24 h
  2. filtrationThe precipitated piperazine hydrochloride was filtered off with suction
  3. washwashed with tetrahydrofuran
  4. customConcentration of the solution in vacuo resulted in 19 g of 2-methyl-4-piperazino-pyrimidine
  5. customwhich was reacted without further purification

出典と根拠

ORDレコード
ord-1684b2b7aac043178849f16e01f9be81
出典データセット
uspto-grants-1992_08
特許番号
US05138058

反応ノート

読み込み中…