Furfural → 2-Bromo-1-(2-furyl)-2-nitroethanol

HRID 846871

反応式

HRID 846871 の反応式
[Br:1][C:2]([N+:9]([O-:11])=[O:10])=[CH:3][C:4]1[O:5][CH:6]=[CH:7][CH:8]=1.C(=O)C1[O:17]C=CC=1.BrC[N+]([O-])=O.C(=O)([O-])[O-].[Na+].[Na+]>O>[Br:1][CH:2]([N+:9]([O-:11])=[O:10])[CH:3]([C:4]1[O:5][CH:6]=[CH:7][CH:8]=1)[OH:17]

参加物

6

反応物 4

HCID 7362FurfuralHCID 10340Sodium CarbonateHCID 68423BromonitromethaneHCID 540943622-(2-Bromo-2-nitroethen-1-yl)furan

生成物 1

HCID 111180202-Bromo-1-(2-furyl)-2-nitroethanol

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

The use of 2-(2-Bromo-2-nitroethenyl)furan as an antimicrobial with a broad spectrum of uses in water treatment, pulp and paper manufacturing, metal working fluids and various non-oxidizing biocide applications has been described. One process for producing BNEF comprises the reaction of furfural with bromonitromethane using a primary amine or primary amine salt and sodium carbonate as the catalytic agent at 10 mol% to produce an intermediate 2-Bromo-1-(2-furyl)-2-nitroethanol, which is dehydrated in the presence of acid to the desired product. The preferred solvent is ethanol. In a typical procedure, the reaction mixture is stirred for 25 hours at 5° C., and the acid is then added to effect the dehydration. The reaction mixture is extracted with methylene chloride and the crude product recovered as an oil which is steam-distilled. The solid product is filtered from the steam-distillate and recrystallized from ethanol, and the yield is reported to be in the range of 23%.

後処理

  1. customOne process for producing BNEF

出典と根拠

ORDレコード
ord-187937edea4c414f8d710db635a219f5
出典データセット
uspto-grants-1992_08
特許番号
US05138076

関連ノート

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