2-tert-Butoxycarbonylamino-3-octadecylcarbamoyloxypropylamine → 2-Cyanomethyl-3-hexadecyloxypropylamine

HRID 847015ノート

反応式

HRID 847015 の反応式
[N:1]([CH2:4][CH:5]([CH2:24][C:25]#[N:26])[CH2:6][O:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[N+]=[N-].C(OC(C)CC(COC(=O)NCCCCCCCCCCCCCCCCCC)CN)(=O)C1C=CC=CC=1.C(OC(NC(COC(=O)NCCCCCCCCCCCCCCCCCC)CN)=O)(C)(C)C>[Pd].CO>[C:25]([CH2:24][CH:5]([CH2:6][O:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH2:4][NH2:1])#[N:26]

参加物

6

反応物 3

HCID 148350012-tert-Butoxycarbonylamino-3-octadecylcarbamoyloxypropylamineHCID 148350122-(2-Benzoyloxypropan-1-yl)-3-octadecylcarbamoyloxypropylamineHCID 198842081-Azido-2-cyanomethyl-3-hexadecyloxypropane

生成物 1

HCID 148350132-Cyanomethyl-3-hexadecyloxypropylamine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A suspension of 3.00 g (23 mM) of 1-azido-2-cyanomethyl-3-hexadecyloxypropane V n1b and 300 mg of 10% palladium on charcoal in 100 ml of methanol is hydrogenated as described in (129) and the crude product of the titled compound IV n1 is obtained.

後処理

  1. customis obtained

出典と根拠

ORDレコード
ord-3b6c824d548a4842877ca522fc6c3286
出典データセット
uspto-grants-1992_08
特許番号
US05138067

反応ノート

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