2-(2-Benzoyloxypropan-1-yl)-3-octadecylcarbamoyloxypropylamine → 2-(2-Benzoyloxypropan-1-yl)-3-hexadecylthiopropylamine

HRID 847020ノート

反応式

HRID 847020 の反応式
[N:1]([CH2:4][CH:5]([CH2:24][CH:25]([O:27][C:28](=[O:35])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[CH3:26])[CH2:6][S:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[N+]=[N-].C(OC(C)CC(COC(=O)NCCCCCCCCCCCCCCCCCC)CN)(=O)C1C=CC=CC=1>[Pd].CO>[C:28]([O:27][CH:25]([CH3:26])[CH2:24][CH:5]([CH2:6][S:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH2:4][NH2:1])(=[O:35])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1

参加物

5

反応物 2

HCID 148350122-(2-Benzoyloxypropan-1-yl)-3-octadecylcarbamoyloxypropylamineHCID 198841951-Azido-2-(2-benzoyloxypropan-1-yl)-3-hexadecylthiopropane

生成物 1

HCID 148350152-(2-Benzoyloxypropan-1-yl)-3-hexadecylthiopropylamine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture is 1.291 g (2.56 mM) of 1-azido-2-(2-benzoyloxypropan-1-yl)-3-n-hexadecylthiopropane m12b, 130 mg of 10% palladium on charcoal in 130 ml of methanol is hydrogenated by the same procedure as described in (129) and crude product of the titled compound m13 is obtained.

出典と根拠

ORDレコード
ord-009f987007b5436c9d88830f80a46847
出典データセット
uspto-grants-1992_08
特許番号
US05138067

反応ノート

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