Ethyl bromoacetate → Ethyl 2-(4,6-dimethylpyrimidin-2-yl)oxyacetate

HRID 847117

反応式

HRID 847117 の反応式
[OH:1][C:2]1[N:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[N:3]=1.Br[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH3:9][C:4]1[CH:5]=[C:6]([CH3:8])[N:7]=[C:2]([O:1][CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:3]=1

参加物

5

反応物 3

HCID 7748Ethyl bromoacetateHCID 95084,6-Dimethylpyrimidin-2-olHCID 11430Potassium Carbonate

生成物 1

HCID 3410252Ethyl 2-(4,6-dimethylpyrimidin-2-yl)oxyacetate収率 26.8%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

2-Hydroxy-4,6-dimethyl pyrimidine (10g, 0.08 mol) was dissolved in 150ml of dimethylformamide. Ethyl bromoacetate (13.5g, 0.08 mol) was added and also, subsequently, 11.lg of potassium carbonate. The reaction mixture was refluxed overnight. A precipitate had formed which was filtered off and the solvent was then evaporated off from the filtrate to form a crude oily product. Following purification by flash chromatography, 4.5g of the title product were obtained in the form of a red oil.

後処理

  1. temperatureThe reaction mixture was refluxed overnight
  2. customA precipitate had formed which
  3. filtrationwas filtered off
  4. customthe solvent was then evaporated off from the filtrate
  5. customto form a crude oily product
  6. custompurification by flash chromatography

出典と根拠

ORDレコード
ord-83d2bb0b404543c793d87e333bd2852c
出典データセット
uspto-grants-1992_08
特許番号
US05139563

関連ノート

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