Ethyl bromoacetate → Ethyl 2-(4,6-dimethylpyrimidin-2-yl)oxyacetate
反応式
[OH:1][C:2]1[N:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[N:3]=1.Br[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH3:9][C:4]1[CH:5]=[C:6]([CH3:8])[N:7]=[C:2]([O:1][CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:3]=1参加物
5
実験手順
2-Hydroxy-4,6-dimethyl pyrimidine (10g, 0.08 mol) was dissolved in 150ml of dimethylformamide. Ethyl bromoacetate (13.5g, 0.08 mol) was added and also, subsequently, 11.lg of potassium carbonate. The reaction mixture was refluxed overnight. A precipitate had formed which was filtered off and the solvent was then evaporated off from the filtrate to form a crude oily product. Following purification by flash chromatography, 4.5g of the title product were obtained in the form of a red oil.
後処理
- temperatureThe reaction mixture was refluxed overnight
- customA precipitate had formed which
- filtrationwas filtered off
- customthe solvent was then evaporated off from the filtrate
- customto form a crude oily product
- custompurification by flash chromatography
出典と根拠
- ORDレコード
- ord-83d2bb0b404543c793d87e333bd2852c
- 出典データセット
- uspto-grants-1992_08
- 特許番号
- US05139563
反応ノート
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