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Water → 1-(5-Tert-Butoxycarbonyl-2-Nitrophenoxy)-2-(5-Methyl-2-Nitrophenoxy)Ethane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 反応物 | Benzene, 2-(2-bromoethoxy)-4-methyl-1-nitro- | HCID 13685252 | — |
| 生成物 | 1-(5-Tert-Butoxycarbonyl-2-Nitrophenoxy)-2-(5-Methyl-2-Nitrophenoxy)Ethane | HCID 19880870 | — |
反応手順
A mixture of Compound 3e (239 mg, 1 mmol), 1-bromo-2-(5-methyl-2-nitrophenoxy)ethane, see G. Grynkiewicz, et al. (1985), (286 mg, 1.1 mmol), K2CO3 (83 mg, 0.6 mmol) in dry N-methylpyrrolidinone (0.75 mL) was heated at 140° C. for 10 min with protection from moisture, cooled and H2O added dropwise to precipitate the product, Compound 3f. After filtration, recrystallization from EtOH gave a white solid, m.p. 113°-114° C. Yield, 383 mg (92%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05141627 |
| 出典データセット | uspto-grants-1992_08 |
| ORD ID | ord-643677538a22494e9ce56617fc2e9b36 |
| 出典メモ | uspto-grants-1992_08 |