Potassium Hydroxide → HCID 19881314、化合物

反応式

C([O:3][C:4](=O)[CH:5]([C:7]1[CH:8]=[N:9][NH:10][C:11]=1[C:12]1[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[CH:14][CH:13]=1)[CH3:6])C.Cl.[NH2:26][OH:27].[OH-].[K+]>CO>[CH2:18]([C:15]1[CH:16]=[CH:17][C:12]([C:11]2[NH:10][N:9]=[CH:8][C:7]=2[CH:5]([CH3:6])[C:4]([NH:26][OH:27])=[O:3])=[CH:13][CH:14]=1)[CH2:19][CH2:20][CH2:21][CH2:22][CH3:23]

参加物

反応条件

温度: -5 °C

実験手順

10 g 5-(4-n-hexylphenyl)-1H-pyrazol-4-yl-propionic acid ethyl ester dissolved in 40 ml methanol are added rapidly to a solution of 4.2 g hydroxylamine hydrochloride and 5 g KOH in 40 ml methanol, pre-cooled to -5° C. After reaching room temperature, the reaction mixture is stirred for 24 hrs. The mixture is filtered and the solvent concentrated under vacuum. The residue is dissolved in ethyl acetate, washed with water, dried with Na2SO4 and solvent removed by evaporation under vacuum. The title compound is crystallised from ethyl ether/hexane: m.p.=150°-155° C.