Methyl iodide → N-(2,6-dichlorobenzoyl)-N-(methoxymethyl)-N'-(4-chlorophenyl)-urea

HRID 847466

反応式

HRID 847466 の反応式
[Cl:1][C:2]1[CH:20]=[CH:19][CH:18]=[C:17]([Cl:21])[C:3]=1[C:4]([NH:6][C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=1)=[O:8])=[O:5].[OH-].[K+].CI.[CH3:26][O:27][CH2:28]Cl>CN(C)C=O>[Cl:1][C:2]1[CH:20]=[CH:19][CH:18]=[C:17]([Cl:21])[C:3]=1[C:4]([N:6]([CH2:26][O:27][CH3:28])[C:7]([NH:9][C:10]1[CH:11]=[CH:12][C:13]([Cl:16])=[CH:14][CH:15]=1)=[O:8])=[O:5]

参加物

6

反応物 4

HCID 6328Methyl iodideHCID 7864Chloromethyl Methyl EtherHCID 14797Potassium HydroxideHCID 923002,6-dichloro-N-(((4-chlorophenyl)amino)carbonyl)benzamide

生成物 1

HCID 19006383N-(2,6-dichlorobenzoyl)-N-(methoxymethyl)-N'-(4-chlorophenyl)-urea

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

10.3 g of N-(2,6-dichlorobenzoyl)-N'-(4-chlorophenyl)-urea and 1.88 g of powdered potassium hydroxide (90%) are dissolved 40 ml of dimethyl formamide, after which 4.7 g of methyl iodide are added drop by drop to the clear solution. The resulting reaction is exothermic. After stirring for two hours the solution is diluted with ice water and the solid substance is isolated. Yield 10.3 g. Melting point 124°-126° C. In a completely similar manner but using methoxymethylchloride instead of methyliodide, N-(2,6-dichlorobenzoyl)-N-(methoxymethyl)-N'-(4-chlorophenyl)-urea is produced. Melting point 121.5°-122.5° C.

後処理

  1. customThe resulting reaction
  2. customthe solid substance is isolated

出典と根拠

ORDレコード
ord-59538ddac0e142dab7d9da6a207aef0d
出典データセット
uspto-grants-1992_08
特許番号
US05142064

関連ノート

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