Hydrochloric Acid → 3-(2,6-Dichlorobenzoyl)-1-(p-chlorophenyl)-hydantoin

HRID 847467

反応式

HRID 847467 の反応式
[Cl:1][C:2]1[CH:20]=[CH:19][CH:18]=[C:17]([Cl:21])[C:3]=1[C:4]([NH:6][C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=1)=[O:8])=[O:5].[C:22](Cl)(=O)[C:23](Cl)=[O:24].NC(N)=O.Cl>ClCCCl>[Cl:1][C:2]1[CH:20]=[CH:19][CH:18]=[C:17]([Cl:21])[C:3]=1[C:4]([N:6]1[C:23](=[O:24])[CH2:22][N:9]([C:10]2[CH:11]=[CH:12][C:13]([Cl:16])=[CH:14][CH:15]=2)[C:7]1=[O:8])=[O:5]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 1176UreaHCID 65578Oxalyl chlorideHCID 923002,6-dichloro-N-(((4-chlorophenyl)amino)carbonyl)benzamide

生成物 1

HCID 190064153-(2,6-Dichlorobenzoyl)-1-(p-chlorophenyl)-hydantoin

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

実験手順

10.3 g of N-(2,6-dichlorobenzoyl)-N'-(p-chlorophenyl)-urea are boiled in 100 ml of dry 1,2-dichloroethane containing 3 ml of oxalylchloride for 24 hours. The urea dissolves with the evolution of hydrochloric acid. After concentration by evaporation and after the addition of 25 ml of ligroin the residue becomes crystalline. The substance mauy be recrystallized from 30 mls of benzene. Melting point 157° C. Yield 8 g.

後処理

  1. concentrationAfter concentration
  2. customby evaporation
  3. additionafter the addition of 25 ml of ligroin the residue
  4. customThe substance mauy be recrystallized from 30 mls of benzene

出典と根拠

ORDレコード
ord-1d4e2ea2bb504f7b8f8c05fc2fff3709
出典データセット
uspto-grants-1992_08
特許番号
US05142064

関連ノート

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