反応式
[N:1]1([C:7]2[N:12]=[CH:11][CH:10]=[CH:9][N:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[Br:13][C:14]1[N:15]([CH2:21][C:22](O)=[O:23])[C:16]([Br:20])=[C:17]([Br:19])[N:18]=1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.CN(C=O)C>O>[N:12]1[CH:11]=[CH:10][CH:9]=[N:8][C:7]=1[N:1]1[CH2:6][CH2:5][N:4]([C:22](=[O:23])[CH2:21][N:15]2[C:16]([Br:20])=[C:17]([Br:19])[N:18]=[C:14]2[Br:13])[CH2:3][CH2:2]1参加物
6
実験手順
7.3 mL 2-piperazin-1-yl-pyrimidine was added to a mixture of 17 g (2,4,5-tribromo-imidazol-1-yl)-acetic acid, 16.6 g TBTU, 7.3 mL TEA and 100 mL DMF. The reaction mixture was stirred for 2 h at RT and subsequently added to water. The precipitate was filtered to give 23 g desired product. Rt: 0.93 (method B), ESI+: 507
後処理
- filtrationThe precipitate was filtered
出典と根拠
- ORDレコード
- ord-3c9d00cd6745421b9277a10b4b73c6d5
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08846948B2
関連ノート
読み込み中…