HCID 12939743、化合物 → HCID 12939745、化合物
反応式
[NH:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]=[C:2]1[S:10][CH:11]([C:16](=O)[C:17]1[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=1)[CH2:12][C:13]([OH:15])=[O:14]>FC(F)(F)C(O)=O>[Cl:23][C:20]1[CH:21]=[CH:22][C:17]([C:16]2[N:1]3[C:9]4[C:4]([N:3]=[C:2]3[S:10][C:11]=2[CH2:12][C:13]([OH:15])=[O:14])=[N:5][CH:6]=[CH:7][CH:8]=4)=[CH:18][CH:19]=1参加物
3
実験手順
17 g (0.047 m) of 3-(imidazo[4,5-b]pyridine-2-ylthio)-3-(4-chlorobenzoyl)propionic acid, prepared according to Example 2, is dissolved in 200 ml trifluoroacetic acid, and the solution is heated to gentle reflux overnight. The solution is cooled and filtered, the solvent is removed in vacuo and the residual solid triturated with ether and the solid collected. The resulting trifluoroacetate is disproportionated in hot acetonitrile to give 9.3 g of title compound, m.p. 250°-252° C.
後処理
- temperaturethe solution is heated
- temperatureto gentle reflux overnight