関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Sunitinib methanesulfonate | HCID 86691059 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Sunitinib | HCID 5329102 | 99.5% |
反応手順
Sunitinib methanesulfonate (1.0 g) and H2O (60 mL) was added into a flask in r.t. and heated to 80° C., the mixture turned clear. The pH of the mixture was adjusted to 8˜9 with 1N NaOH and cooled r.t., was stirred overnight, filtered, washed, and dried in vacuo to give 0.65 g of crude sunitinib with 99.2% purity by HPLC analysis in 99.5% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08846953B2 |
|---|
| 出典データセット | uspto-grants-2014_09 |
|---|
| ORD ID | ord-b24cd80ef32e41859a7e5c7bd4853404 |
|---|
| 出典メモ | uspto-grants-2014_09 |
|---|
