Diethyl Ether → Ethyl 2-Aminobutyrate Hydrochloride
反応式
[NH2:1][CH:2]([CH2:6][CH3:7])[C:3]([OH:5])=[O:4].S(Cl)([Cl:10])=O.[CH2:12](OCC)[CH3:13]>C(O)C>[ClH:10].[NH2:1][CH:2]([CH2:6][CH3:7])[C:3]([O:5][CH2:12][CH3:13])=[O:4]参加物
5
反応条件
- 温度
- 0 °C
実験手順
A slurry of 2-aminobutyric acid (100 g, Aldrich) in absolute ethanol (300 ml) was stirred under nitrogen at 0° C. and thionyl chloride (120.8 g) was added dropwise. The reaction was stirred overnight at 0° C. and then gradually warmed to room temperature. The resulting white slurry was heated under reflux for 3 hours, left to cool for 10 minutes, then poured into chilled diethyl ether (600 ml), with hand stirring. The suspension was filtered and the solid product dried to give the desired product (150 g) as a white solid. 1H NMR consistent with proposed structure.
後処理
- temperaturegradually warmed to room temperature
- temperatureThe resulting white slurry was heated
- temperatureunder reflux for 3 hours
- waitleft
- temperatureto cool for 10 minutes
- additionpoured
- stirringwith hand stirring
- filtrationThe suspension was filtered
- customthe solid product dried
出典と根拠
- ORDレコード
- ord-57d496f8cfa74e14b0b60ed9b08a5969
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05723458
反応ノート
読み込み中…