Diisopropylethylamine → (R)-2-(3-bromo-4-cyanophenylamino)-3-phenylpropanamide

HRID 84816

反応式

HRID 84816 の反応式
[Br:1][C:2]1[CH:9]=[C:8](F)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[NH2:11][C@@H:12]([C:20]([NH2:22])=[O:21])[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.CCN(C(C)C)C(C)C>CS(C)=O>[Br:1][C:2]1[CH:9]=[C:8]([NH:11][C@H:12]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:20]([NH2:22])=[O:21])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

参加物

5

反応物 3

HCID 81531DiisopropylethylamineHCID 1189392-Bromo-4-fluorobenzonitrileHCID 7000171(2R)-2-amino-3-phenylpropanamide

生成物 1

HCID 67509091(R)-2-(3-bromo-4-cyanophenylamino)-3-phenylpropanamide収率 23.3%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

A solution of 2-bromo-4-fluorobenzonitrile (255 mg, 1.27 mmol), D-phenylalanine amide (220 mg, 1.34 mmol) and DIEA (0.466 mL, 2.68 mmol) in DMSO (3 mL) was stirred at 100 C for 18 h. The mixture was then purified by HPLC to give (R)-2-(3-bromo-4-cyanophenylamino)-3-phenylpropanamide (102 mg).

後処理

  1. customThe mixture was then purified by HPLC

出典と根拠

ORDレコード
ord-e9254a9343a04fa4b0ed05ac1403204f
出典データセット
uspto-grants-2014_09
特許番号
US08846928B2

関連ノート

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