2-Aminothiophenol → Benzenamine, 2-((1,2,4-oxadiazol-3-ylmethyl)thio)-

HRID 848170ノート

反応式

HRID 848170 の反応式
[Na].[NH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[SH:9].Cl[CH2:11][C:12]1[N:16]=[CH:15][O:14][N:13]=1>C(O)C>[NH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9][CH2:11][C:12]1[N:16]=[CH:15][O:14][N:13]=1

参加物

5

反応物 3

HCID 87132-AminothiophenolHCID 27357653-(Chloromethyl)-1,2,4-oxadiazoleHCID 5360545Sodium

生成物 1

HCID 3057622Benzenamine, 2-((1,2,4-oxadiazol-3-ylmethyl)thio)-

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Sodium (1.27 g; 0.055 mol) was dissolved in absolute ethanol (50 ml) and to this was added 2-aminothiophenol (7.38 g; 0.059 mol). To the resulting solution was added 3-chloromethyl-1,2,4-oxadiazole (6.59 g; 0.055 mol) dropwise over 10 minutes. The resulting mixture was then stirred at ambient temperature for 30 minutes, sodium chloride removed by filtration and the filtrate was evaporated to dryness under reduced pressure to give 3-(2-aminophenylthiomethyl)-1,2,4-oxadiazole which was re-crystallised from isopropanol; m.p. 57°.

後処理

  1. customsodium chloride removed by filtration
  2. customthe filtrate was evaporated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-8a42b7c4c1d94c35863f966d25765d11
出典データセット
uspto-grants-1981_10
特許番号
US04294843

反応ノート

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