Isopropylamine → Methanesulfonamide, 1-chloro-N-(1-methylethyl)-

HRID 848397ノート

反応式

HRID 848397 の反応式
[CH:1]([NH2:4])([CH3:3])[CH3:2].[Cl:5][CH2:6][S:7](Br)(=[O:9])=[O:8]>ClCCl>[CH:1]([NH:4][S:7]([CH2:6][Cl:5])(=[O:9])=[O:8])([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 6363IsopropylamineHCID 12543458Chloromethanesulfonyl bromide

生成物 1

HCID 3016718Methanesulfonamide, 1-chloro-N-(1-methylethyl)-

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
25 °C

実験手順

A 11.8 g (0.2 mol) sample of isopropylamine was added dropwise to a cooled (-60° C.) solution of 19.3 g (0.1 mol) chloromethanesulfonyl bromide in 200 ml dichloromethane. The reaction was then allowed to warm to about 25° C. and stirred about 16 hours. The reaction mixture was then filtered, washed with water, dried over magnesium sulfate and evaporated to give crude N-isopropyl chloromethanesulfonamide.

後処理

  1. filtrationThe reaction mixture was then filtered
  2. washwashed with water
  3. dry with materialdried over magnesium sulfate
  4. customevaporated

出典と根拠

ORDレコード
ord-36509b1a801c469981dcacf5ecb71e11
出典データセット
uspto-grants-1981_10
特許番号
US04295874

反応ノート

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