Hydrogen Bromide → 4-keto-L-proline hydrobromide

HRID 848447

反応式

HRID 848447 の反応式
C([N:11]1[CH2:18][C:17](=[O:19])[CH2:16][C@H:12]1[C:13]([OH:15])=[O:14])(OCC1C=CC=CC=1)=O.[BrH:20]>C(O)(=O)C>[BrH:20].[O:19]=[C:17]1[CH2:18][NH:11][C@H:12]([C:13]([OH:15])=[O:14])[CH2:16]1

参加物

4

反応物 2

HCID 260Hydrogen BromideHCID 11076282N-Carbobenzyloxy-4-keto-L-proline

生成物 1

HCID 127736614-keto-L-proline hydrobromide

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To 4.0 g. (0.015 mole) of N-carbobenzyloxy-4-keto-L-proline are added 20 ml. of hydrogen bromide in acetic acid (30-32%). The mixture is frequently swirled over a period of eight minutes. At the end of this period (effervescence has stopped), the yellow-orange solution is layered over with 250 ml. of ether, triturating the gummy product. The ether is discarded and the resulting tacky solid is triturated with fresh ether and finally with 50 ml. of acetonitrile to give 4-keto-L-proline, hydrobromide as a crystalline solid weighing 2.7 g. (85%), m.p. 153°-155° (dec.,), [α]D26 -49° (c, 1% in water).

後処理

  1. customof ether, triturating the gummy product
  2. customthe resulting tacky solid is triturated with fresh ether and finally with 50 ml

出典と根拠

ORDレコード
ord-65f5391bedc94b09bc9e382f5da62b09
出典データセット
uspto-grants-1981_10
特許番号
US04296113

関連ノート

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