Heptadecanoic Acid → Heptadecanoyl Chloride

HRID 848937

反応式

HRID 848937 の反応式
[C:1]([OH:19])(=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].S(Cl)([Cl:22])=O>C1CCCCC1>[C:1]([Cl:22])(=[O:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]

参加物

4

反応物 2

HCID 10465Heptadecanoic Acid2 回HCID 24386Thionyl Chloride2 回

生成物 1

HCID 3516438Heptadecanoyl Chloride収率 81.6%

試薬・触媒・溶媒 1

HCID 8078Cyclohexane溶媒

反応条件

温度
80 °C

実験手順

In a one L (liter) two-necked flask were placed 102.1 g (0.38 mol) of heptadecanoic acid and 200 milliliter (mL) of cyclohexane, and the flask was equipped with a 100 mL dropping funnel containing 67.3 g (0.57 mol) of thionyl chloride and a reflux tube. Then, the heptadecanoic acid was completely dissolved under heating and stirring of the flask in an oil bath at 80° C. Thereafter the thionyl chloride was added dropwise over a period of 2 hours, and further the oil bath was maintained at 80° C. for one hour. From the resultant reaction mixture were removed the cyclohexane and the thionyl chloride under reduced pressure by means of an aspirator. The resultant reaction mixture was subjected to vacuum distillation. Thus 88.5 g (0.31 mol) of heptadecanoyl chloride was obtained in a yield of 81.2% based on the fed heptadecanoic acid.

後処理

  1. customthe flask was equipped with a 100 mL
  2. temperatureunder heating
  3. temperaturefurther the oil bath was maintained at 80° C. for one hour
  4. customFrom the resultant reaction mixture
  5. customwere removed the cyclohexane
  6. customThe resultant reaction mixture
  7. distillationwas subjected to vacuum distillation

出典と根拠

ORDレコード
ord-dc386b59b929450298c6b7b545141946
出典データセット
uspto-grants-2000_01
特許番号
US06010708

関連ノート

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