Acetic Acid → 6-(1-Carbamoylcyclopentylamino)-5-fluoro-2-(quinolin-3-ylamino)nicotinamide

HRID 84922

反応式

[C:1]([C:3]1[CH:4]=[C:5]([F:29])[C:6]([NH:20][C:21]2([C:26]([NH2:28])=[O:27])[CH2:25][CH2:24][CH2:23][CH2:22]2)=[N:7][C:8]=1[NH:9][C:10]1[CH:11]=[N:12][C:13]2[C:18]([CH:19]=1)=[CH:17][CH:16]=[CH:15][CH:14]=2)#[N:2].[OH-].[Na+].OO.CC(O)=[O:36]>CCO.CS(C)=O>[C:26]([C:21]1([NH:20][C:6]2[C:5]([F:29])=[CH:4][C:3]([C:1]([NH2:2])=[O:36])=[C:8]([NH:9][C:10]3[CH:11]=[N:12][C:13]4[C:18]([CH:19]=3)=[CH:17][CH:16]=[CH:15][CH:14]=4)[N:7]=2)[CH2:25][CH2:24][CH2:23][CH2:22]1)(=[O:27])[NH2:28]

参加物

実験手順

To a solution of crude 1-(5-cyano-3-fluoro-6-(quinolin-3-ylamino)pyridin-2-ylamino)cyclopentanecarboxamide in EtOH (2 mL) and DMSO (1 mL), aq. 1N NaOH (1 mL) and aq. H2O2 (50%, 1 mL) were added. The mixture was stirred for 1 h. HOAc (0.5 mL) was added. It was concentrated in vacuo. The residue was purified by HPLC to give the titled compound (41 mg). MS 409.4 (M+H); UV 224.1, 243.7, 302.6, 324.8 nm; t 0.495 min.

後処理

concentrationIt was concentrated in vacuo
customThe residue was purified by HPLC

出典と根拠

ORDレコード: ord-62fde1b06d2c4b6c80ab01e03411e537
出典データセット: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08846928B2

反応式

参加物

反応物 4

生成物 1

試薬・触媒・溶媒 2

実験手順

後処理

出典と根拠

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