Chloroacetyl chloride → Chloroacetic acid morpholine carboxamide

HRID 849447

反応式

HRID 849447 の反応式
[Cl:1][CH2:2][C:3](Cl)=[O:4].C[N:7]1CC[O:10]CC1.[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1>ClCCl>[N:13]1([C:3]([NH2:7])=[O:4])[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1.[Cl:1][CH2:2][C:3]([OH:4])=[O:10]

参加物

5

反応物 3

HCID 6577Chloroacetyl chlorideHCID 79724-MethylmorpholineHCID 8083Morpholine

生成物 1

HCID 88103447Chloroacetic acid morpholine carboxamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Combine chloroacetyl chloride (2.00 mL, 25.0 mmol) and N-methylmorpholine (2.76 mL, 25.0 mmol) in dichloromethane (100 mL). Cool in an ice-bath. Add morpholine (2.19 mL, 25.0 mmol) and stir in the ice-bath for 1 hour. Warm to ambient temperature and stir for 1 hour. Extract with cold aqueous 5% sulfuric acid solution, saturated aqueous sodium bicarbonate solution, and saturated aqueous sodium chloride solution. Dry the organic layer over Na2SO4, filter, and evaporate in vacuo to obtain chloroacetic acid morpholine carboxamide.

後処理

  1. temperatureCool in an ice-bath
  2. extractionExtract with cold aqueous 5% sulfuric acid solution, saturated aqueous sodium bicarbonate solution, and saturated aqueous sodium chloride solution
  3. dry with materialDry the organic layer over Na2SO4
  4. filtrationfilter
  5. customevaporate in vacuo

出典と根拠

ORDレコード
ord-86733740ae21419f9a26178bcedcdca5
出典データセット
uspto-grants-2000_01
特許番号
US06013645

関連ノート

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