Piperazine → 4-(Piperazin-1-yl)benzene-1-sulfonamide
反応式
F[C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[NH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>O>[N:12]1([C:2]2[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][CH:3]=2)[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1参加物
4
反応条件
- 温度
- 100 °C
実験手順
A mixture of 4-fluorobenzenesulfonamide (6.95 g) and piperazine (17.1 g) in 30 mL of water is heated at 100° C. overnight. The solid is then collected, washed with water and toluene, and dried under reduced pressure to give 9.2 g of 4-(piperazin-1-yl)benzenesulfonamide; mp 219-221° C.; ms m/z 241; IR (mineral oil) 1160, 822, 1332, 608, 1593, 1137 cm-1. 1H NMR (DMSOd6) δ 2.81, 3.17, 2.3, 7.01, 7.07, 7.61.
後処理
- customThe solid is then collected
- washwashed with water and toluene
- customdried under reduced pressure
出典と根拠
- ORDレコード
- ord-04797938215e4ceb83bc79bdad90df9d
- 出典データセット
- uspto-grants-2000_01
- 特許番号
- US06013654
反応ノート
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