Thionyl Chloride → 2-Acetylthiomethyl-3-phenyl-propionyl chloride
反応式
[C:1]([S:4][CH2:5][C@H:6]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:7](O)=[O:8])(=[O:3])[CH3:2].S(Cl)([Cl:19])=O>>[C:1]([S:4][CH2:5][CH:6]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:7]([Cl:19])=[O:8])(=[O:3])[CH3:2]参加物
3
実験手順
2.0 g (8.40 mmol) of (R)-2-acetylthiomethyl-3-phenylpropanoic acid (Ia R) (Example 1, stage e) are placed in a round-bottomed flask. The flask is cooled by an ice-water bath and 1.2 g (10.08 mmol) of thionyl chloride are added dropwise. The mixture is stirred overnight to room temperature.
後処理
- temperatureThe flask is cooled by an ice-water bath
出典と根拠
- ORDレコード
- ord-09377bdea0a4475086783cea02161020
- 出典データセット
- uspto-grants-2000_01
- 特許番号
- US06013829
反応ノート
読み込み中…