Sodium Hydroxide → HCID 54549528、化合物
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:12]=[CH:13][C:14]=1[C:15](=[O:18])[NH:16][CH3:17])[CH:6]=[CH:7][C:8]([O:10]C)=[O:9].[OH-].[Na+]>CO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:12]=[CH:13][C:14]=1[C:15](=[O:18])[NH:16][CH3:17])[CH:6]=[CH:7][C:8]([OH:10])=[O:9]参加物
4
反応条件
- 温度
- 50 °C
実験手順
To a solution of methyl 3-methoxy-4-(methylcarbamoyl)-cinnamate (300 mg) in methanol was added 1H aqueous sodium hydroxide solution (1.5 ml) at ambient temperature, and the mixture was stirred for 5 hours at 50° C. The solvent was removed, and water was added thereto. The mixture was washed with diethyl ether and adjusted to pH 4 with 1N hydrochloric acid. The resulting precipitate was collected by filtration and washed with water to give 3-methoxy-4-(methylcarbamoyl)-cinnamic acid (250 mg).