Benzoyl Peroxide → HCID 54161484、化合物

HRID 850335ノート

反応式

HRID 850335 の反応式
[C:1]([O:5][C:6](=[O:23])[CH2:7][C:8]1[CH:13]=[C:12]([C:14]([CH3:17])([CH3:16])[CH3:15])[C:11]([OH:18])=[C:10]([C:19]([CH3:22])([CH3:21])[CH3:20])[CH:9]=1)([CH3:4])([CH3:3])[CH3:2].[Br:24]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[C:1]([O:5][C:6](=[O:23])[CH:7]([C:8]1[CH:9]=[C:10]([C:19]([CH3:22])([CH3:21])[CH3:20])[C:11]([OH:18])=[C:12]([C:14]([CH3:17])([CH3:16])[CH3:15])[CH:13]=1)[Br:24])([CH3:3])([CH3:4])[CH3:2]

参加物

5

反応物 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 53661891HCID 53661891、化合物

生成物 1

HCID 54161484HCID 54161484、化合物

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

反応条件

温度
60 °C

実験手順

To a solution of Intermediate 18 (1.0314 g, 3.22 mmol) in 7.3 mL CCl4 was added N-bromosuccinimide (0.5827 g) and a catalytic amount of benzoyl peroxide. The reaction was heated to 60° C. overnight. The solvent was removed in vacuo. The residue was taken up in ethyl acetate, washed with water and brine, dried over MgSO4, and concentrated to an orange oil (0.8654 g, 2.17 mmol), which was used in the next step without further purification.

後処理

  1. customThe solvent was removed in vacuo
  2. washwashed with water and brine
  3. dry with materialdried over MgSO4
  4. customwas used in the next step without further purification

出典と根拠

ORDレコード
ord-0ce330ad76c646dd803ca64e3cbe2446
出典データセット
uspto-grants-2000_01
特許番号
US06017918

反応ノート

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