4-Benzyloxybenzylamine → 4-Hydroxybenzylamine

HRID 850463

反応式

HRID 850463 の反応式
C([O:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13][NH2:14])=[CH:11][CH:10]=1)C1C=CC=CC=1.[H][H]>[C].[Pd].C1COCC1>[OH:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13][NH2:14])=[CH:11][CH:10]=1

参加物

5

反応物 2

HCID 42928454-BenzyloxybenzylamineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 974724-Hydroxybenzylamine収率 85%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 8028Tetrahydrofuran溶媒

実験手順

10% Palladium-carbon catalyst (water content 50%, 50 mg) was added to a solution of 4-benzyloxybenzylamine (530 mg, 2.485 mmol, 1.0 eq) in THF (10 ml), and the mixture was stirred for 3 hours at room temperature in a stream of hydrogen. The reaction mixture was filtered through Celite, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by column chromatography (n-hexane/ethyl acetate=1/1) to give 4-hydroxybenzylamine (260 mg, 85.0%).

後処理

  1. filtrationThe reaction mixture was filtered through Celite
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe obtained residue was purified by column chromatography (n-hexane/ethyl acetate=1/1)

出典と根拠

ORDレコード
ord-cb6bd5b742c84021a56ca1cda3c9581f
出典データセット
uspto-grants-2000_01
特許番号
US06017919

関連ノート

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