4-Benzyloxybenzylamine → 4-Hydroxybenzylamine
反応式
C([O:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13][NH2:14])=[CH:11][CH:10]=1)C1C=CC=CC=1.[H][H]>[C].[Pd].C1COCC1>[OH:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13][NH2:14])=[CH:11][CH:10]=1参加物
5
実験手順
10% Palladium-carbon catalyst (water content 50%, 50 mg) was added to a solution of 4-benzyloxybenzylamine (530 mg, 2.485 mmol, 1.0 eq) in THF (10 ml), and the mixture was stirred for 3 hours at room temperature in a stream of hydrogen. The reaction mixture was filtered through Celite, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by column chromatography (n-hexane/ethyl acetate=1/1) to give 4-hydroxybenzylamine (260 mg, 85.0%).
後処理
- filtrationThe reaction mixture was filtered through Celite
- concentrationthe filtrate was concentrated under reduced pressure
- customThe obtained residue was purified by column chromatography (n-hexane/ethyl acetate=1/1)
出典と根拠
- ORDレコード
- ord-cb6bd5b742c84021a56ca1cda3c9581f
- 出典データセット
- uspto-grants-2000_01
- 特許番号
- US06017919
反応ノート
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