Quinoline → Ethyl 3-aminopent-4-enoate

HRID 850623

反応式

HRID 850623 の反応式
N1C2C(=CC=CC=2)C=CC=1.[H][H].[CH2:13]([O:15][C:16](=[O:22])[CH2:17][CH:18]([NH2:21])[C:19]#[CH:20])[CH3:14]>CCO.[Pd].[O-]S([O-])(=O)=O.[Ba+2]>[CH2:13]([O:15][C:16](=[O:22])[CH2:17][CH:18]([NH2:21])[CH:19]=[CH2:20])[CH3:14]

参加物

6

反応物 3

HCID 7047QuinolineHCID 22006121Ethyl 3-amino-4-pentynoateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 10057602Ethyl 3-aminopent-4-enoate収率 185.1%

試薬・触媒・溶媒 2

HCID 16218511Pd barium sulfate触媒HCID 702Ethanol溶媒

実験手順

A mixture of 5% Pd/BaSO4 (0.025 g) and quinoline (0.30 mL) was stirred under a ballon of hydrogen for 30 minutes. 3-Amino-pent-4-ynoic acid ethyl ester 17-1 (1.77 g, 10.0 mmol) in EtOH (15 mL) was added and the solution stirred for an additional 2.5 hours. The solution was filtered through a pad of celite and concentrated in vacuo to provide 2.65 g of crude product 19-1.

後処理

  1. filtrationThe solution was filtered through a pad of celite
  2. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-d1d55e3e70e0485588959b6a2941dcb8
出典データセット
uspto-grants-2000_01
特許番号
US06017926

関連ノート

読み込み中…