Sodium Hydroxide → 10-bromo-5-carboxy-2-methoxy-4H-pyrido[3,2,1-jk]carbazole-4-one

HRID 850778ノート

反応式

HRID 850778 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]3[CH:19]=[C:18]([C:20]([O:22]CC)=[O:21])[C:17](=[O:25])[C:8]4[CH:9]=[C:10]([O:15][CH3:16])[CH:11]=[C:12]([C:13]=2[CH:14]=1)[C:7]3=4.[OH-].[Na+]>C(O)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]3[CH:19]=[C:18]([C:20]([OH:22])=[O:21])[C:17](=[O:25])[C:8]4[CH:9]=[C:10]([O:15][CH3:16])[CH:11]=[C:12]([C:13]=2[CH:14]=1)[C:7]3=4

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 2125285710-bromo-5-ethoxycarbonyl-2-methoxy-4H-pyrido [3,2,1-jk]carbazole-4-one

生成物 1

HCID 2125282410-bromo-5-carboxy-2-methoxy-4H-pyrido[3,2,1-jk]carbazole-4-one収率 83.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

10-bromo-5-ethoxycarbonyl-2-methoxy-4H-pyrido[3,2,1-jk]carbazole-4-one (400 mg) obtained in Example 98 was suspended in ethanol (10 ml), and 1N sodium hydroxide (3 ml) was added. The mixture was stirred at room temperature for 12 hours, and the solvent was evaporated under reduced pressure. To the residue was added 1N hydrochloric acid to pH 1, and the crystals precipitated were recovered by filtration, and washed with ethanol and ether to obtain the title compound (310 mg, 83%).

後処理

  1. customthe solvent was evaporated under reduced pressure
  2. additionTo the residue was added 1N hydrochloric acid to pH 1
  3. customthe crystals precipitated
  4. filtrationwere recovered by filtration
  5. washwashed with ethanol and ether

出典と根拠

ORDレコード
ord-eb1ca7c767a94670b4a82836f5b06137
出典データセット
uspto-grants-2000_01
特許番号
US06018046

反応ノート

読み込み中…