Sodium Hydroxide → 1,1-Dimethylethyl N-[(1S,2S,4S)-4-amino-2-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]carbamate

HRID 850857ノート

反応式

HRID 850857 の反応式
C(O)(=O)C(O)=O.[C:7]([O:11][C:12]([NH:14][C@H:15]([C@@H:23]([OH:34])[CH2:24][C@@H:25]([NH2:33])[CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:13])([CH3:10])([CH3:9])[CH3:8].[OH-].[Na+]>C1(C)C=CC=CC=1>[C:7]([O:11][C:12]([NH:14][C@H:15]([C@@H:23]([OH:34])[CH2:24][C@@H:25]([NH2:33])[CH2:26][C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)[CH2:16][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1)=[O:13])([CH3:10])([CH3:8])[CH3:9]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 70191891HCID 70191891、化合物

生成物 1

HCID 103178781,1-Dimethylethyl N-[(1S,2S,4S)-4-amino-2-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]carbamate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

(2S,3S,5S)-2-tert-Butoxycarbonylamino-3-hydroxy-5-amino-1,6-diphenylhexane oxalate (500 mg, 1.05 mmol) obtained in Example 43 (A) was suspended in toluene (5 ml). An aqueous solution (5 ml) of NaOH (200 mg) was added thereto and the mixture was vigorously stirred, then separated. The organic layer was washed with water and dried over anhydrous magnesium sulfate. The desiccant was filtered off, and the filtrate was concentrated to give the desired compound as colorless crystals. Yield: 340 mg (84%).

後処理

  1. customseparated
  2. washThe organic layer was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. filtrationThe desiccant was filtered off
  5. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-46a79619164e4a008046c648909a75d9
出典データセット
uspto-grants-2000_01
特許番号
US06018069

反応ノート

読み込み中…