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Triethylamine → 2-(N-benzyloxycarbonyl-DL-isoleucylamino)-1,3,4-thiadiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Ethyl chloroformate | HCID 10928 | — |
| 反応物 | 1,3,4-Thiadiazol-2-amine | HCID 19909 | — |
| 反応物 | N-benzyloxycarbonyl-L-isoleucine | HCID 102945 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 2-(N-benzyloxycarbonyl-DL-isoleucylamino)-1,3,4-thiadiazole | HCID 13145510 | 82% |
反応手順
9.6 g of N-benzyloxycarbonyl-DL-isoleucine, 3.7 g of triethylamine, 150 ml of chloroform, 3.9 of ethyl chlorocarbonate and 3.7 g of 2-amino-1,3,4-thiadiazole were subjected to a reaction similar to that in Example 1(i) to obtain 10.3 g (yield: 82%) of 2-(N-benzyloxycarbonyl-DL-isoleucylamino)-1,3,4-thiadiazole as white crystals having a melting point of 145°-149° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04382142 |
| 出典データセット | uspto-grants-1983_05 |
| ORD ID | ord-bdbea7241ecf4a59911e525684781f99 |
| 出典メモ | uspto-grants-1983_05 |