1,3,4-Thiadiazol-2-amine → 2-(N-benzyloxycarbonyl-DL-isoleucylamino)-1,3,4-thiadiazole

HRID 850953

反応式

HRID 850953 の反応式
[CH2:1]([O:8][C:9]([NH:11][CH:12]([C:17]([OH:19])=O)[CH:13]([CH2:15][CH3:16])[CH3:14])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:20][C:21]1[S:22][CH:23]=[N:24][N:25]=1>>[CH2:1]([O:8][C:9]([NH:11][CH:12]([C:17]([NH:20][C:21]1[S:22][CH:23]=[N:24][N:25]=1)=[O:19])[CH:13]([CH2:15][CH3:16])[CH3:14])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 199091,3,4-Thiadiazol-2-amineHCID 102945N-benzyloxycarbonyl-L-isoleucine

生成物 1

HCID 131455102-(N-benzyloxycarbonyl-DL-isoleucylamino)-1,3,4-thiadiazole収率 56.6%

実験手順

26.5 g of N-benzyloxycarbonyl-DL-isoleucine and 10 g of 2-amino-1,3,4-thiadiazole were reacted in the same manner as in Example 3(i) to obtain 19.5 g (yield: 56%) of 2-(N-benzyloxycarbonyl-DL-isoleucylamino)-1,3,4-thiadiazole as white crystals having a melting point of 149° C.

出典と根拠

ORDレコード
ord-867032a5d88647ba8c89db7026dadd3d
出典データセット
uspto-grants-1983_05
特許番号
US04382142

関連ノート

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