Cyclopentylamine → N-[3-(2-anilino-4-pyrimidinyl)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-5-yl]-N-cyclopentylamine

HRID 8510

反応式

HRID 8510 の反応式
Cl[C:2]1[CH:7]=[CH:6][N:5]2[N:8]=[C:9]([C:24]3[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=3)[C:10]([C:11]3[CH:16]=[CH:15][N:14]=[C:13]([NH:17][C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[N:12]=3)=[C:4]2[CH:3]=1.C1(P(C2C=CC=CC=2)C2C=CC3C(=CC=CC=3)C=2C2C3C(=CC=CC=3)C=CC=2P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(=O)([O-])[O-].[Cs+].[Cs+].C(OCC)(=O)C.[CH:89]1([NH2:94])[CH2:93][CH2:92][CH2:91][CH2:90]1>C([O-])(=O)C.[Pd+2].C([O-])(=O)C.O>[NH:17]([C:13]1[N:12]=[C:11]([C:10]2[C:9]([C:24]3[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=3)=[N:8][N:5]3[CH:6]=[CH:7][C:2]([NH:94][CH:89]4[CH2:93][CH2:92][CH2:91][CH2:90]4)=[CH:3][C:4]=23)[CH:16]=[CH:15][N:14]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

参加物

8

反応物 5

HCID 2906CyclopentylamineHCID 8857Ethyl AcetateHCID 10796Cesium carbonateHCID 634876Binap, (A+-)-2 回HCID 112470274-[5-chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-phenyl-2-pyrimidinamine

生成物 1

HCID 22350049N-[3-(2-anilino-4-pyrimidinyl)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-5-yl]-N-cyclopentylamine収率 36%

試薬・触媒・溶媒 2

HCID 167845palladium(II) acetate触媒2 回HCID 962Water溶媒

反応条件

温度
100 °C

実験手順

To a solution of 4-[5-chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-phenyl-2-pyrimidinamine (100 mg, 0.24 mmol) in cyclopentylamine (5 mL) was added successively racemic-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (72 mg), cesium carbonate (200 mg), and palladium (II) acetate (16 mg). The resulting mixture was stirred at 100° C. for 24 hours, then additional racemic-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (72 mg) and palladium (II) acetate (16 mg) were added and the reaction stirred at 100° C. for additional 24 hours, at which time the reaction was judged complete by thin layer chromatography. The solution was cooled to room temperature and ethyl acetate and water were added to the reaction mixture. The phases were separated, and the aqueous phase again extracted with ethyl acetate. The combined organic phases were dried (magnesium sulfate), filtered and concentrated. The resulting residue was purified by flash chromatography (1:1 hexanes:ethyl acetate) to give N-[3-(2-anilino-4-pyrimidinyl)-2-(4-fluorophenyl)pyrazolo[1,5-α]pyridin-5-yl]-N-cyclopentylamine (40 mg, 36%) as a solid. 1H NMR (CDCl3): δ 8.21 (d, 1H), 8.13 (d, 1H), 7.65 (m, 4H), 7.4–7.24 (m, 4H), 7.18 (t, 21H), 7.06 (t, 1H), 6.44 (d 1H), 6.30 (dd, 1H), 4.16 (d, 1H), 3.68 (m, 1H), 1.4–2.2 (m, 8H); 19F-NMR (CDCl3): δ−113.32; MS m/z 466 (M+1).

後処理

  1. stirringthe reaction stirred at 100° C. for additional 24 hours, at which time the reaction
  2. temperatureThe solution was cooled to room temperature
  3. customThe phases were separated
  4. extractionthe aqueous phase again extracted with ethyl acetate
  5. dry with materialThe combined organic phases were dried (magnesium sulfate)
  6. filtrationfiltered
  7. concentrationconcentrated
  8. customThe resulting residue was purified by flash chromatography (1:1 hexanes:ethyl acetate)

出典と根拠

ORDレコード
ord-87058de6158440a7af624a3373595eef
出典データセット
uspto-grants-2006_08
特許番号
US07087618B2

関連ノート

読み込み中…