2-Bromobutane → 1-Sec.-butyl-4-methoxypyrazole

HRID 851148ノート

反応式

HRID 851148 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[N:5][NH:6][CH:7]=1.O1[CH2:12][CH2:11][CH2:10][CH2:9]1.C(Br)(CC)C>O>[CH:10]([N:5]1[CH:4]=[C:3]([O:2][CH3:1])[CH:7]=[N:6]1)([CH2:11][CH3:12])[CH3:9]

参加物

5

反応物 3

HCID 65542-BromobutaneHCID 8028TetrahydrofuranHCID 53247764-methoxy-1H-pyrazole

生成物 1

HCID 130184051-Sec.-butyl-4-methoxypyrazole収率 42%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
70 °C

実験手順

A mixture of 23.6 g (0.21 mol) of potassium tert.-butylate, 19.6 g (0.2 mol) of 4-methoxypyrazole (for the preparation, see Archiv der Pharmazie 300 (1967), pages 704-708), 100 ml of tetrahydrofuran and 28.7 g (0.21 mol) of sec.-butyl bromide was stirred at 70° C. for 18 hours. 300 ml of water were then added and the mixture was extracted 3 times with 100 ml of chloroform each time. The combined organic phases were dried over sodium sulphate and evaporated in vacuo. 13.2 g (42% of theory) of 1-sec.-butyl-4-methoxypyrazole were obtained from the residue, by vacuum distillation, in the form of a colorless oil with a boiling point of 60° C./0.2 mm Hg.

後処理

  1. customfor the preparation
  2. extractionthe mixture was extracted 3 times with 100 ml of chloroform each time
  3. dry with materialThe combined organic phases were dried over sodium sulphate
  4. customevaporated in vacuo

出典と根拠

ORDレコード
ord-dea0d5e4ed284266bcee492e9f1ef468
出典データセット
uspto-grants-1983_05
特許番号
US04382947

反応ノート

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