3-Bromo-1-propanol → 1-[4-(3-Hydroxypropyloxy)phenyl]propan-2-one
反応式
C1[O:14][C:4]([CH3:13])([CH2:5][C:6]2[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=2)OC1.[OH-].[Na+].Br[CH2:18][CH2:19][CH2:20][OH:21]>O>[OH:21][CH2:20][CH2:19][CH2:18][O:12][C:9]1[CH:8]=[CH:7][C:6]([CH2:5][C:4](=[O:14])[CH3:13])=[CH:11][CH:10]=1参加物
5
実験手順
1-(4-Hydroxyphenyl)propan-2-one ethylene ketal (3.88 g) was added to a solution of sodium hydroxide (1.5 g) in water (30 ml) and the mixture was stirred at room temperature for 30 minutes. 1-Bromo-3-hydroxypropane (2.98 g) was added and the mixture was boiled under reflux with stirring for 11/2 hours. After cooling water (50 ml) was added, the mixture was extracted with ether, the extracts dried (MgSO4) and evaporated to give the title compound (3.94 g) as its ethylene ketal.
後処理
- temperatureunder reflux
- stirringwith stirring for 11/2 hours
- additionwas added
- extractionthe mixture was extracted with ether
- dry with materialthe extracts dried (MgSO4)
- customevaporated
出典と根拠
- ORDレコード
- ord-f9fb21408b294431a90c83cd983e6cf7
- 出典データセット
- uspto-grants-1983_05
- 特許番号
- US04382958
反応ノート
読み込み中…