3,4,5-Trimethoxyphenol → 1,2,3,4-Tetrahydro-8,9,10-trimethoxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one hydrochloride

HRID 851185

反応式

HRID 851185 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([OH:13])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[ClH:14].O=[C:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH:17]1[C:22](OC)=[O:23]>>[ClH:14].[CH3:12][O:11][C:7]1[C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[C:4]2[C:16]3[CH2:21][CH2:20][NH:19][CH2:18][C:17]=3[C:22](=[O:23])[O:13][C:5]=2[CH:6]=1

参加物

3

反応物 2

HCID 695053,4,5-TrimethoxyphenolHCID 2724028Methyl 4-oxopiperidine-3-carboxylate hydrochloride

生成物 1

HCID 131369141,2,3,4-Tetrahydro-8,9,10-trimethoxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one hydrochloride収率 55%

実験手順

Prepared by the method described in Example 1 from 3,4,5-trimethoxyphenol (25 g, 0.14 moles) and methyl 4-oxo-3-piperidinecarboxylate hydrochloride (18.8 g, 0.097 moles). Recrystallization from dilute aqueous hydrochloric acid yielded the product (17.5 g) as the hydrochloride, mp 232°-234° C.

後処理

  1. customPrepared by the method
  2. customRecrystallization from dilute aqueous hydrochloric acid

出典と根拠

ORDレコード
ord-32bc5c3456fd4bc0b985babfe6c8a89f
出典データセット
uspto-grants-1983_05
特許番号
US04382939

関連ノート

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