Benzophenone → 1,1-Diphenyl-5-methoxy-1-pentanol

HRID 851301

反応式

HRID 851301 の反応式
[Mg].Br[CH2:3][CH2:4][CH2:5][CH2:6][O:7][CH3:8].[C:9]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)(=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>CCOCC>[C:17]1([C:9]([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)([OH:16])[CH2:3][CH2:4][CH2:5][CH2:6][O:7][CH3:8])[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

参加物

5

反応物 3

HCID 3102BenzophenoneHCID 5211681-Bromo-4-methoxybutaneHCID 5462224Magnesium

生成物 1

HCID 131250861,1-Diphenyl-5-methoxy-1-pentanol

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒3 回

実験手順

To a suspension of 3.9 g. (0.16 mole) of magnesium turnings in 300 ml. of dry ether was added dropwise 26.7 g. (0.16 mole) of 1-bromo-4-methoxybutane in 80 ml. of ether and the mixture refluxed for four hours. The reaction mixture was cooled and 14.6 g. (0.008 mole) of benzophenone in 100 ml. of dry ether was added dropwise. The mixture was stirred at ambient temperature for 18 hours, cautiously quenched with water and the ether layer separated. The aqueous layer was extracted with ether and the combined ether extract was dried and concentrated to give 1,1-diphenyl-5-methoxy-1-pentanol, m.p. 112°-115° C.

後処理

  1. additionTo a suspension of 3.9 g
  2. temperatureThe reaction mixture was cooled
  3. customcautiously quenched with water
  4. customthe ether layer separated
  5. extractionThe aqueous layer was extracted with ether
  6. extractionthe combined ether extract
  7. customwas dried
  8. concentrationconcentrated

出典と根拠

ORDレコード
ord-f96ea3d11f8141bb8c275c39b317d715
出典データセット
uspto-grants-1983_05
特許番号
US04383999

関連ノート

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