Methanol → 1-(2-Methyl-3-phenyl-propyl)-piperidine

HRID 851319

反応式

HRID 851319 の反応式
[CH3:1][C:2](=[CH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH:3]=O.CO.[NH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1.[H][H]>[Pd].O>[CH3:1][CH:2]([CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH2:3][N:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1

参加物

7

反応物 4

HCID 887MethanolHCID 75572-Methylcinnamic aldehydeHCID 8082PiperidineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 141495841-(2-Methyl-3-phenyl-propyl)-piperidine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 962Water溶媒

実験手順

A mixture of 1000 g of α-methyl-cinnamaldehyde, 10 liters of methanol and 640 g of piperidine are placed under a nitrogen atmosphere and 50 g of palladium/carbon are added thereto. The mixture is then hydrogenated while cooling with water to 30° C. internal temperature. Hydrogenation continued until the hydrogen uptake has been completed. The catalyst was filtered off and the methanol was distilled under vacuum. Distillation of the crude produce yielded pure 1-(2-methyl-3-phenyl-propyl)-piperidine, b.p. 92° C./0.04 Torr.

後処理

  1. filtrationThe catalyst was filtered off
  2. distillationthe methanol was distilled under vacuum
  3. distillationDistillation of the crude
  4. customproduce

出典と根拠

ORDレコード
ord-8e1a18fbdbb64a47a565f2ed7c64cc37
出典データセット
uspto-grants-1983_05
特許番号
US04384116

関連ノート

読み込み中…