Hydrochloric Acid → 2-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridine-7-carboxylic acid

HRID 85144ノート

反応式

HRID 85144 の反応式
C([O:3][C:4]([C:6]1[C:7]2[N:14]=[C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[C:21]([F:24])([F:23])[F:22])[NH:12][C:8]=2[CH:9]=[N:10][CH:11]=1)=[O:5])C.Cl>[OH-].[Na+].C(O)C>[F:24][C:21]([F:22])([F:23])[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[C:13]1[NH:12][C:8]2[CH:9]=[N:10][CH:11]=[C:6]([C:4]([OH:5])=[O:3])[C:7]=2[N:14]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 672030302-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridine-7-carboxylic acid ethyl ester

生成物 1

HCID 672044002-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridine-7-carboxylic acid収率 85%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

2-(2-Trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridine-7-carboxylic acid ethyl ester (80; 2.35 g, 7 mmol) was taken up in 10% aqueous NaOH (40 mL) and ethanol (20 mL). The reaction mixture was stirred under reflux for 30 min. Upon cooling to room temperature, the reaction mixture was acidified with 5N HCl. The resulting yellow solids were collected by filtration, washed with water, and dried to afford 2-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridine-7-carboxylic acid 81 (1.77 g, 85%).

後処理

  1. temperatureunder reflux for 30 min
  2. filtrationThe resulting yellow solids were collected by filtration
  3. washwashed with water
  4. customdried

出典と根拠

ORDレコード
ord-2ecdf8d9e0bd4a57b471a76896c109d5
出典データセット
uspto-grants-2014_09
特許番号
US08846947B2

反応ノート

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