5-Methyl-4-(4-nitro-phenyl)-imidazole → 4-(5-Methyl-1H-imidazol-4-yl)aniline

HRID 851748ノート

反応式

HRID 851748 の反応式
[CH3:1][C:2]1[NH:6][CH:5]=[N:4][C:3]=1[C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][CH:8]=1.[H][H]>CO.[Pd]>[CH3:1][C:2]1[NH:6][CH:5]=[N:4][C:3]=1[C:7]1[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9][CH:8]=1

参加物

5

反応物 2

HCID 235073515-Methyl-4-(4-nitro-phenyl)-imidazoleHCID 178418361HCID 178418361、化合物

生成物 1

HCID 235076304-(5-Methyl-1H-imidazol-4-yl)aniline収率 88%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

Sixty grams of 5-methyl-4-(4-nitrophenyl)-1-H-imidazole dissolved in methanol was hydrogenated in the presence of 0.7 gm of 5% Pd catalyst at atmospheric pressure and at room temperature. When the calculated amount of hydrogen was taken up, the catalyst was filtered off, and the solution was evaporated to dryness to yield 45 gm of 5-methyl-4-(4-aminophenyl)-1-H-imidazole.

後処理

  1. filtrationthe catalyst was filtered off
  2. customthe solution was evaporated to dryness

出典と根拠

ORDレコード
ord-900f2d852ef0466183ad7397bf58a7f1
出典データセット
uspto-grants-1983_05
特許番号
US04386099

反応ノート

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